PDRN Polydeoxyribonucleotide
PDRN (Polydeoxyribonucleotide) is a premium cosmetic‑grade ingredient purified from premium salmon milt DNA via advanced multi‑stage biotechnology.
PDRN can be degraded by DNases into oligonucleotides and nucleotides, which then participate in cellular endocytic pathways via A2A receptor agonism and salvage pathways.
Through strict cosmetic‑grade refining processes developed by Mincoo, most allergens, impurities, and macromolecular residues are removed, delivering safe, skin‑friendly, high‑purity raw materials suitable for daily skincare formulation.
Featuring high biocompatibility with human DNA, cosmetic‑grade PDRN can be rapidly absorbed and recognized by skin cells without irritation. It effectively stimulates cellular regeneration, boosts fibroblast activity and collagen synthesis, and strengthens the skin barrier function. Meanwhile, it relieves skin inflammation, calms redness and sensitivity, and accelerates the repair of damaged and stressed skin.
Widely formulated in essence, moisturizing cream and various skincare products, PDRN provides long‑term deep hydration, smooths fine lines, improves rough texture, and restores resilient, youthful and healthy skin. Ideal for sensitive, post‑procedure, and aging skin, it delivers mild yet powerful rejuvenating effects.
Application
Used for high‑end skincare raw materials, enhancing product efficacy, development of functional cosmetics for repair, stability maintenance, anti‑aging, etc.
● High‑end skincare raw material formulation.
● Repair‑oriented functional cosmetic development.
● Post‑procedure soothing skincare products.
● Anti‑aging & skin barrier‑strengthening formulas.
Core Advantages
Mincoo Cosmetic‑Grade PDRN Raw Material Highlights
High purity
Exclusive separation and extraction technology ensures a purity of over 95%, guaranteeing biological activity.
Optimized manufacturing process
Stable and gentle manufacturing process, ensuring maximum activity.
Precise molecular weight control
The average molecular weight range is 100‑3500 kDa, customizable.
Wide application
Compatible with various dosage forms.
Supporting materials
Possessing a complete set of biosafety and efficacy evaluation materials.
Quality system guarantee
The raw material of PDRN, salmon milt, is from FAO61 fishing zone. The entire process, including production, storage, and shipment, is traceable.
Product features
Fully dissolves into a colourless, crystal-clear liquid, with no cloudiness or sediment to ruin your finished cosmetic look.
Efficacy Test Data
Anti‑Wrinkle Efficacy
The in vitro anti‑wrinkle test demonstrated that PDRN significantly promoted Type I collagen expression in human fibroblasts.
PDRN significantly inhibits ROS production, effectively combating oxidative stress.
Firming Efficacy
The in vitro firming test showed that PDRN significantly enhanced elastin expression in human fibroblasts.
PDRN significantly enhances elastin expression, improving skin firmness and elasticity.
Hair Loss Prevention
Significant increase in VEGF expression in human dermal papilla cells, demonstrating potent anti‑hair loss potential.
PDRN significantly increases VEGF expression in dermal papilla cells, supporting hair retention.
Soothing Efficacy
Significantly inhibited IL‑6 inflammatory factor expression in LPS‑stimulated macrophages.
PDRN significantly inhibits IL‑6 release, soothing sensitive skin.
Antioxidant Efficacy
Demonstrated significant inhibition of ROS production in H₂O₂‑stimulated human fibroblasts.
PDRN significantly inhibits ROS production, effectively combating oxidative stress.
Lightening Efficacy
Significantly reduced melanin content in B16‑F10 melanoma cells, proving effective lightening capability.
PDRN significantly reduced melanin content in B16-F10 melanoma cells, demonstrating its lightening efficacy.
Cosmetic Raw Material Submission Code
| No. | Submission Code | INCI Name | Molecular Weight Range (Da) |
|---|---|---|---|
|
1
|
000383-13622-1250
|
DNA Sodium
|
MW 100,000–500,000
|
|
2
|
000383-13622-6876
|
DNA Sodium
|
MW 500,000–1,000,000
|
|
3
|
000383-13622-1762
|
DNA Sodium
|
MW 1,000,000–1,500,000
|
|
4
|
000383-13622-7553
|
DNA Sodium
|
MW >1,500,000
|
