PDRN/PN Polydeoxynucleotide/Polynucleotide
PDRN Medical Grade is a high‑purity medical raw material refined from premium salmon milt DNA via a stable, validated manufacturing process.
Through gentle processing, the proteins, impurities, and allergens are removed as much as possible; it meets medical-grade safety standards for clinical and injectable applications.
With ultra‑high DNA homology with human skin tissue, salmon‑derived PDRN delivers excellent biocompatibility, low rejection risk, and stable bioactivity.
It accelerates tissue repair, relieves inflammation, promotes cell regeneration, and improves skin resilience, widely used in medical aesthetic injections, medical aesthetics, joint cavity repair, and clinical repair formulations.
Application
Wound healing and tissue repair (such as diabetic foot, burns). Potential applications in fields such as orthopedics, ophthalmology, and gynecology.
Skin repair, improvement of skin quality, anti-aging, and scar reduction. Widely used in medical beauty projects, such as water injection therapy, microneedling, skin revitalization products, and dermal fillers, etc.
Advantages
Natural source
Extracted from salmon milt, sustainably sourced from the certified FAO61 fishing zone.
Multi‑stage manufacturing process
Stable and gentle manufacturing process. Strict multi‑stage purification workflow.
Precise enzymatic hydrolysis process
Accurate molecular weight control, supporting customization from 100~3500 kDa.
Hyperchromicity
Hyperchromicity is >40%, with a high content of double-stranded DNA.
Low bacterial endotoxins
Bacterial endotoxins are <0.05 EU/mg (with industry comparison benchmark).
Gel formation after sterilization
At a concentration of 1.5% aqueous solution, Medical Grade PDRN maintained a good gel state after moist‑heat sterilization at 121°C for 15 minutes.
Zero ToxicityNo acute systemic toxicity observed.
Non‑IrritantScore 0.00 in irritation tests.
Full ComplianceMeets all medical device standards.
Safety Evaluation Reports
Medical Device Raw Material Master File
Mincoo’s Polydeoxyribonucleotide Master File has been registered with the Center for Medical Device Evaluation, NMPA.
The publicized information can be found on the Center for Medical Device Evaluation NMPA website. The website address is as follows: https://www.cmde.org.cn/xwdt/zwddjxxgs/20210413105900664.html
| No. | Master File Owner | Master File Registration Item Name | Master File Registration Number | Registration/Update Date |
|---|---|---|---|---|
| 1374 | Shandong Mincoo Biotech Co., Ltd. | Polydeoxyribonucleotide Raw Material Master File | M2026155-000 | 2026/4/24 |
